Methods and reagents for predicting clinical outcome and...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2726569

The invention relates to methods for the prediction of the clinical outcome of a patient suffering from cancer based on the relative expression levels of BRCA1 and RAP80 genes. The invention also relates to anticancer combination therapies comprising a platinum-based chemotherapeutic agent and an inhibitor of RAP80.

Cette invention concerne des procédés permettant de prédire le résultat clinique d'un patient atteint de cancer, sur la base des niveaux d'expression relatifs des gènes BRCA1 et RAP80. L'invention concerne en outre des polythérapies anticancéreuses comprenant un agent chimiothérapeutique à base de platine et un inhibiteur de RAP80.

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