Trail receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2295719

A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL- R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.

Cette invention se rapporte à une protéine appelée récepteur de TRAIL (TRAIL-R) qui se lie à la protéine connue comme ligand induisant l'apoptose et associée au TNF (TRAIL TNF-related apoptosis-inducing ligand). Ce récepteur de TRAIL s'avère utile pour purifier la protéine TRAIL ou pour inhiber les activités de cette protéine. Cette invention se rapporte aussi à des séquences d'ADN isolées qui codent les polypeptides de TRAIL-R, ainsi qu'à des vecteurs d'expression contenant ces séquences d'ADN, et à des cellules hôtes transformées par de tels vecteurs d'expression recombinés. Cette invention se rapporte enfin à des anticorps qui sont immunoréactifs vis à vis du récepteur TRAIL-R.

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