Substituted benzylaminoquinuclidines

Details Substituted benzylaminoquinuclidines Substituted benzylaminoquinuclidines

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/435 (2006.01) A61K 31/675 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2146259

Compounds useful in the treatment of inflammatory disorders, central nervous system disorders and other disorders of formula (I), and the pharmaceutically acceptable salts thereof, wherein Ar1 and Ar2 are each independently aryl or substituted aryl; R1 is alkyl having from 1 to 6 carbon atoms; R2 is hydrogen or alkyl having from 1 to 6 carbon atoms; and either X and Y are taken separately and they are each, independently, hydrogen, dialkylphosphoryl having 2 to 12 carbon atoms, alkyl having from 1 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms or alkynyl having from 2 to 6 carbon atoms; or X and Y are taken together and they represent a hydrocarbon chain having 3, 4, or 5 carbon atoms, optionally containing up to 2 double bonds and optionally having 1 or 2 substituents selected from oxo, hydroxy and alkyl having from 1 to 6 carbon atoms; provided that when X and Y are taken together they are attached to adjacent carbon atoms; and provided that if either X or Y is hydrogen, then the other one must be alkenyl or alkynyl.

Composés utiles dans le traitement des troubles inflammatoires, des affections du système nerveux central et d'autres maladies, et sels pharmaceutiquement acceptables de ces derniers; ces composés sont représentés par la formule (I) où Ar1 et Ar2 sont, indépendamment l'un de l'autre, un aryle ou un aryle substitué; R1 est un alkyle de 1 à 6 atomes de carbone; R2 est un hydrogène ou un alkyle de 1 à 6 atomes de carbone; et X et Y sont pris séparément et correspondent, indépendamment l'un de l'autre, à un hydrogène, un dialkylphosphoryle de 2 à 12 atomes de carbone, un alkyle de 1 à 6 atomes de carbone, un alkényle de 2 à 6 atomes de carbone ou un alkynyle de 2 à 6 atomes de carbone; ou X et Y sont pris ensemble et correspondent à une chaîne hydrocarbonée de 3, 4 ou 5 atomes de carbone, contenant facultativement jusqu'à 2 doubles liaisons et portant facultativement 1 ou 2 substituants choisis parmi les groupes oxo, hydroxy et alkyle de 1 à 6 atomes de carbone; à la condition que lorsque X et Y sont pris ensemble, ils sont liés aux atomes de carbone adjacents; et à la condition que si X ou Y est un atome d'hydrogène, l'autre doit être un alkényle ou un alkynyle.

Affiliated with

Also associated with

Rating

Substituted benzylaminoquinuclidines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted benzylaminoquinuclidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted benzylaminoquinuclidines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1352987