Thermoprotected microparticle compositions and process for...

Details Thermoprotected microparticle compositions and process for... Thermoprotected microparticle compositions and process for...

A - Human Necessities

61

K

A61K 47/24 (2006.01) A61K 9/08 (2006.01) A61K 31/496 (2006.01) A61K 31/573 (2006.01) A61K 38/13 (2006.01) A61K 47/10 (2006.01) A61L 2/07 (2006.01)

Patent

CA 2333648

Compositions of submicron- to micron-sized particles of water-insoluble biologically active substances that are stabilized by thermoprotecting agents, can be terminally steam sterilized without any significant increase of mean particle size. These compositions display markedly reduced heat-induced coagulation, flocculation, or particle size growth during the terminal steam sterilization process.

L'invention porte sur des compositions de particules, allant des particules submicroniques aux particules de l'ordre du micromètre, de substances biologiquement actives insolubles dans l'eau qui sont stabilisées par des agents thermoprotecteurs, ces compositions pouvant être stérilisées à la vapeur après conditionnement sans que la taille moyenne des particules soit considérablement augmentée. Ces compositions présentent une coagulation induite par la chaleur, une floculation ou une taille de particule sensiblement réduites lors du processus de stérilisation à la vapeur après conditionnement.

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