Serpentine electrophoresis channel with self-correcting bends

Details Serpentine electrophoresis channel with self-correcting bends Serpentine electrophoresis channel with self-correcting bends

G - Physics

01

N

G01N 27/447 (2006.01) B01D 57/02 (2006.01) G01N 30/28 (2006.01) G01N 30/38 (2006.01) G01N 30/60 (2006.01)

Patent

CA 2307623

A serpentine electrophoresis channel, e.g., for a microchip format, is disclosed. The channel includes pairs of linear segments, e.g., parallel or right-angle segments, each joined by an angled channel region having a first curved channel portion subtending an angle .alpha. f>.alpha. where .alpha. is the angle between segments in a pair, and a second curved channel portion subtending an angle .alpha. s = .alpha. f-.alpha.. The angles and cross sections of the two channel portions are such that .delta.t f, the time differential of analyte migration at inner and outer tracks in the first curved portion is equal to .delta.t s, the time differential of analyte migration at outer and inner tracks in the second curved portion, respectively.

L'invention concerne un canal d'électrophorèse en serpentin, par exemple, pour un format de micropuce. Le canal comprend des paires de segments linéaires, par exemple, des segments parallèles ou en angle droit, chacun joint par une région de canal angulaire ayant une première partie de canal courbée sous-tendant un angle alpha f> alpha , où alpha représente l'angle entre des segments d'une paire, et une seconde partie de canal courbée sous-tendant un angle alpha s = alpha f- alpha . Les angles et les sections transversales des deux parties de canal sont tels que delta tf, le différentiel des temps de migration de substance analysée au niveau de pistes intérieure et extérieure dans la première partie courbée est égal à delta ts, le différentiel des temps de migration de substance analysée au niveau de pistes intérieure et extérieure dans la seconde partie courbée, respectivement.

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