C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) A61K 31/662 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07F 9/40 (2006.01)
Patent
CA 2739787
The present invention provides .beta.-hydroxy-.gamma.-aminophosphonates, .beta.-amino-.gamma.- aminophosphonates, and analogs thereof that inhibit carnitine acyltransferases. The invention also provides compositions comprising these .beta.-hydroxy-.gamma.-aminophos-phonates, .beta.-amino-.gamma.- aminophosphonates, and analogs, and methods of the use of such compounds and compositions in the treat-ment, amelioration or prevention of pathological conditions, diseases or disorders that are linked with fatty acid metabolism, such as non-insulin dependent diabetes or obesity. The invention also provides processes for the preparation of such compounds and compositions.
Cette invention concerne des ß-hydroxy-?-aminophosphonates, des ß-amino-?- aminophosphonates et leurs analogues qui inhibent les carnitine acyltransférases. Linvention concerne également des compositions contenant ces ß-hydroxy-?-aminophosphonates, ß-amino-?- aminophosphonates et analogues, et des méthodes dutilisation de ces composés et de ces compositions dans le traitement, lamélioration ou la prévention de pathologies, de maladies ou daffections qui sont associées avec le métabolisme des acides gras, notamment le diabète non insulinodépendant ou lobésité. Linvention concerne par ailleurs des procédés de préparation de ces composés et de ces compositions.
Cordero Ricardo Abraham de La Cruz
Loria Jorge Luis Rosado
Vasquez Miguel Angel Duarte
Mbm Intellectual Property Law Llp
Nucitec S.a. de C.v.
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