Method for the diagnosis and treatment of glutamic acid...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/60 (2006.01) A61K 35/14 (2006.01) A61K 38/19 (2006.01) A61K 38/51 (2006.01) A61K 39/00 (2006.01) C12N 9/88 (2006.01) G01N 33/564 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2104225

The present invention relates to the identification, cloning and sequencing of nucleic acid molecules encoding an isoform of the enzyme glutamic acid decarboxylase and further relates to the use of these molecules and/or peptides and polypeptides en- coded thereby in diagnostic tests for Insulin Dependent Diabetes Mellitus and other diseases in which glutamic acid decarboxy- lase is an autoantigen and in the treatment of patients suffering from these diseases.

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