Transfer and expression of gene sequences into central...

C - Chemistry – Metallurgy – 12 – N

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167/202, 195/1.2

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/869 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2039921

ABSTRACT This invention relates to methods of gene delivery to cells in the central nervous system by introducing and expressing gene sequences mediated by herpes simplex virus 1 (HSV-1) vectors with a mutation in a gene for viral replica- tion. A108-08.WP 041690

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