Methods and compositions for detecting hepatitis e virus

G - Physics – 01 – N

Patent

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Details

G01N 33/576 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) A61P 31/14 (2006.01) C07K 14/08 (2006.01) C07K 16/10 (2006.01) C12N 5/10 (2006.01) C12N 15/51 (2006.01) C12Q 1/70 (2006.01) G01N 33/577 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2393500

Disclosed herein are methods and compositions for detecting the presence in a sample of a US-type or a US-subtype hepatitis E virus, including naturally occurring variants thereof. In particular, the invention provides nucleic acid sequences corresponding to the genome of the US-type or US-subtype hepatitis E virus, amino acid sequences, including epitope sequences, encoded by the genomes of such viruses, and antibodies that bind specifically to such amino acid sequences. The invention further provides methods and compositions for immunizing individuals against infection by, or for treating individuals already infected with such a virus.

L'invention concerne des méthodes et des compositions permettant de détecter la présence d'un virus de l'hépatite E de type ou de sous-type US dans un échantillon, y compris ces diverses variantes. En particulier, l'invention concerne des séquences d'acides nucléiques correspondant au génome du virus de l'hépatite E de type ou de sous-type US, des séquences d'acides aminés, y compris des séquences épitopes, codées par les génomes de tels virus. L'invention concerne également des anticorps se fixant tout spécialement à ces séquences d'acides aminés. L'invention concerne également des méthodes et des compositions permettant d'immuniser des individus contre l'infection par un tel virus ou de traiter les individus déjà infectés par un tel virus.

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