Response element compositions and assays employing same

Details Response element compositions and assays employing same Response element compositions and assays employing same

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) C12N 15/52 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2100584

2100584 9216546 PCTABS00016 DNA segments have been discovered, and characterized by sequence, which are response elements operative to confer responsiveness to ligands for several members of the steroid/thyroid superfamily of receptors, for the transcriptional activation and/or repression of promoters in cells. By using transcriptional control regions comprising response elements of the present invention in combination with a functional promoter, it is now possible to provide recombinant DNA vectors containing a gene, the transcription (and, thereby, also expression) of which is under the control of a promoter, the transcriptional activity of which is responsive to ligands for members of the steroid/thyroid superfamily of receptors.

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