C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2451959
Means of treating and/or preventing diseases caused by a splicing variant, neurodegenerative diseases typified by Alzheimer~s disease and so on. A nucleic acid seemingly participating in the formation of a presenilin-2 exon 5- deficient splicing variant; an inhibitor inhibiting the binding between a protein and a nucleic acid causing the splicing variant; and a method of screening the inhibitor.
L'invention concerne des moyens de traiter et/ou de prévenir des maladies causées par un variant d'épissage, des maladies neurodégénératives telles que la maladie d'Alzheimer, etc. L'invention concerne un acide nucléique qui, apparemment, participe à la formation d'un variant d'épissage déficient de la préséniline-2 exon 5; un inhibiteur qui inhibe la liaison entre une protéine et un acide nucléique provoquant le variant d'épissage; ainsi qu'un procédé de criblage de l'inhibiteur.
Ikeda Yoko
Imaizumi Kazunori
Katayama Taiichi
Manabe Takayuki
Tohyama Masaya
Japan Science And Technology Agency
Kirby Eades Gale Baker
Taisho Pharmaceutical Co. Ltd.
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