In situ gel-forming delivery vehicle for bio-affecting...

A - Human Necessities – 61 – K

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A61K 47/30 (2006.01) A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 47/10 (2006.01) A61K 47/32 (2006.01) A61K 49/00 (2006.01) A61K 51/12 (2006.01)

Patent

CA 2192708

An interpolymer complex of a polyacid and a water-soluble, non-ionic polymer, preferably polymethacrylic acid and polyethyleneglycol, which forms a stable, insoluble complex in water at acidic pH, and which is converted to an extrudable liquid upon addition of an appropriate amount of a complex solubilizer, preferably ethanol. The resultant complex is particularly useful as an injectable, sustained release delivery vehicle for bio-affecting substances, including therapeutic agents.

Un complexe interpolymère d'un polyacide et d'un polymère soluble dans l'eau et non-ionique, de préférence l'acide polyméthacrylique et le polyéthylénéglycol forme un complexe stable non-soluble dans l'eau à un pH acide, et est transformé en liquide extrudable par adjonction d'une quantité appropriée d'agent de solubilisation, de préférence de l'éthanol. Le complexe ainsi obtenu est particulièrement utile comme vecteur injectable et à libération prolongée de substances bio-efficaces, et notamment d'agents thérapeutiques.

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