Streptavidin expressed gene fusions and methods of use thereof

Details Streptavidin expressed gene fusions and methods of use thereof Streptavidin expressed gene fusions and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/36 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12N 15/72 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2376192

The present invention provides vectors for expressing genomic streptavidin fusion cassettes. In the various embodiments, fusion proteins produced from these vectors are provided. In particular embodiments, fusion proteins comprising a single chain antibody and genomic streptavidin are provided as are vectors encoding the same. Also provided, are methods of using the fusion proteins of the present invention, and in particular, the use of scFvSA fusion proteins as diagnostic markers or as a cell specific targeting agents.

La présente invention concerne des vecteurs servant à exprimer des cassettes de fusion issues de la streptavidine génomique. Divers modes de réalisation de l'invention décrivent des protéines de fusion obtenues à partir de ces vecteurs. Des modes de réalisation particuliers décrivent des protéines de fusion comprenant un anticorps à chaîne unique et la streptavidine génomique, ainsi que des vecteurs codant lesdites protéines. L'invention concerne en outre des méthodes d'utilisation des protéines de fusion de l'invention et, notamment, l'utilisation de protéines de fusion scFvSA comme marqueurs de diagnostic ou comme agents de ciblage spécifiques à une cellule.

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