C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 225/32 (2006.01) A61K 31/135 (2006.01) A61K 41/00 (2006.01) A61P 35/00 (2006.01) C07D 213/38 (2006.01)
Patent
CA 2426741
The invention involves a methods and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and methods of treatment using these compositions are disclosed. The present invention relates to the field of photosensitizers possessing photodynamic activities. They possess high photodynamic activities and low dark toxicities, which makes them as more potent photodynamic agents than HPD against cancer and AIDS virus.
L'invention concerne des procédés et des compositions s'utilisant en thérapie photodynamique. De nouveaux dérivés de pérylènequinone, des conjugués contenant des dérivés de pérylènequinone et un agent de fixation, ainsi que des traitements utilisant ces compositions sont décrits. L'invention se rapporte au domaine des photosensibilisants possédant des activités photodynamiques. Leurs activités photodynamiques élevées et leurs faibles toxicités dans le noir en font des agents photodynamiques plus puissants que les dérivés d'hématoporphyrine contre le cancer et le virus du SIDA.
Chen Shen
Shen Tao
Wu Tao
Xu Shangjie
Zhang Manhua
Institute Of Photographic Chemistry Academia Sinica
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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