Piperidine oligomers and combinatorial libraries thereof

Details Piperidine oligomers and combinatorial libraries thereof Piperidine oligomers and combinatorial libraries thereof

C - Chemistry, Metallurgy

07

D

C07D 211/62 (2006.01) A61K 31/445 (2006.01) C07D 471/22 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2296428

The present invention relates to piperidine oligomers, methods for the preparation of piperidine oligomers and compound libraries thereof, and the use of piperidine oligomers as drug substances. The present invention also relates to the use of combinatorial libraries of piperidine oligomers for screening purposes. The oligomers have one of the general formulas (I) or (II). Each of the monomers (piperidine carboxylic acids) are linked via amide bonds. The piperidine monomers may carry substituents, particularly hydroxy, hydroxymethyl, and carboxy substituents. The oligomers may be prepared in libraries (arrays) of compounds especially suitable for screening purposes.

L'invention concerne des oligomères de pipéridine, des procédés pour la préparation d'oligomères de pipéridine et des banques de composés de ceux-ci, ainsi que l'utilisation des oligomères de pipéridine en tant que substances médicamenteuses. L'invention concerne également l'utilisation de banques combinatoires d'oligomères de pipéridine à des fins de criblage. Les oligomères sont représentés par les formules générales I ou II. Chaque monomère (acides carboxyliques de pipéridine) est lié par des liaisons amide. Les monomères de pipéridine peuvent porter des substituants, particulièrement des substituants sélectionnés parmi hydroxy, hydroxyméthyle et carboxy. Les oligomères peuvent être préparés dans des banques (réseaux) de composés qui conviennent spécialement au criblage.

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