Pyrazolopyrimidines as protein kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/04 (2006.01) A61K 31/4162 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2624826

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

Dans ses divers modes de réalisation, la présente invention concerne une nouvelle classe de composés pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs de protéines kinases et/ou de kinases point de contrôle, des procédés de préparation de ces composés, des compositions pharmaceutiques renfermant l'un ou plusieurs de ces composés, des procédés destinés à préparer des préparations pharmaceutiques renfermant l'un ou plusieurs de ces composés, ainsi que des méthodes destinées à traiter, prévenir, inhiber ou atténuer une ou plusieurs maladies associées aux protéines kinases ou aux kinases point de contrôle au moyen de ces composés ou de ces compositions pharmaceutiques.

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