A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/00 (2006.01) A61K 9/72 (2006.01) A61K 31/13 (2006.01) A61K 31/197 (2006.01) A61K 31/375 (2006.01) A61K 33/04 (2006.01) A61M 16/00 (2006.01)
Patent
CA 2434930
Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by deliverying into the lung as a gas, agent causing repletion or increase of the GSNO pool or protection against toxicity and does so independently of reaction with oxygen. Agents include ethyl nitrite, NOCl, NOBr, NOF, NOCN, N2O3, HNO, and H2S. Optionally, N-acetylcysteine, ascorbate, H2S or HNO is administered in addition to other GSNO repleting agent to potentiate the effect of said agent.
L'invention concerne le traitement d'affections pulmonaires dans lesquelles le poumon présente un pool de GSNO ou pool de glutathion appauvri et une augmentation d'espèces d'oxygène réactives, par l'apport d'un agent gazeux dans le poumon qui provoque une saturation ou une augmentation du pool de GSNO ou protège contre la toxicité, et ce, indépendamment de la réaction avec l'oxygène. Ces agents comprennent le nitrite d'éthyle, NOCl, NOBr, NOF, NOCN, N¿2?O¿3?, HNO, et H¿2?S. On administre éventuellement de la N-acétylcystéine, de l'ascorbate, H¿2?S ou HNO en plus de l'agent de saturation de GSNO pour potentialiser l'effet de cet agent.
Duke University
Macrae & Co.
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