Substituted imidazole neuropeptide y y5 receptor antagonists

Details Substituted imidazole neuropeptide y y5 receptor antagonists Substituted imidazole neuropeptide y y5 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2393821

Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is =CH- or =N-; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, -S-alkyl, or -CN. R is alkyl, -CF3, cycloalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6- tetrahydropyridine or formula (A), wherein R10 and R11 are hydrogen, alkyl or together form a cycloalkyl, are disclosed, as well as pharmaceutical compositions and methods of using said compounds in the treatment of eating disorders and diabetes.

L'invention concerne des composés de la formule (I) ou bien un sel, un solvate ou un <i>N</i>-oxyde pharmaceutiquement acceptable de ceux-ci, dans laquelle X représente =CH- ou =N-; Y représente H, halogène, trihaloalkyle, alkyle, alcényle, cycloalkyle, cycloalkyle, SH, -S-alkyle ou -CN. R représente alkyle, -CF3, cycloalkyle, hétérocycloalkyle, hétérocycloalkyle-alkyle ou phényle facultativement substitué, phénoxyalkyle, phénylthioalkyle, pyridyle, thiényle, thiazolyle, pyrazinyle, 1,2,5,6-tétrahydropyridine ou (A), où R<10> et R<11> représentent hydrogène, alkyle ou forment ensemble un cycloalkyle. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation desdits composés dans le traitement de troubles de la nutrition et du diabète.

Affiliated with

Also associated with

Rating

Substituted imidazole neuropeptide y y5 receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted imidazole neuropeptide y y5 receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted imidazole neuropeptide y y5 receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1361402