C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/64 (2006.01) A61K 38/13 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2044028
ABSTRACT A cyclosporine metabolite having a molecular weight determined by mass spectrometry of about 1205 and having the following properties: (a) being immunologically distinct from cyclosporine metabolites OL-1, OL-17 and OL-8; (b) being more polar than OL-1 or OL-17 and less polar than OL-8 when eluated from a gradient high performance liquid chromatography; (c) being extractable from bile of test animals which have been administered cyclosporine A; and (d) being substantially free of other cyclosporine metabolites and cyclosporine A, and a physiologically acceptable salt or stereoisomer thereof.
Levy Gary
Wong Pui Y.
Bereskin & Parr
Levy Gary
Wong Pui Y.
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