Cyclosporine metabolites

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/64 (2006.01) A61K 38/13 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2044028

ABSTRACT A cyclosporine metabolite having a molecular weight determined by mass spectrometry of about 1205 and having the following properties: (a) being immunologically distinct from cyclosporine metabolites OL-1, OL-17 and OL-8; (b) being more polar than OL-1 or OL-17 and less polar than OL-8 when eluated from a gradient high performance liquid chromatography; (c) being extractable from bile of test animals which have been administered cyclosporine A; and (d) being substantially free of other cyclosporine metabolites and cyclosporine A, and a physiologically acceptable salt or stereoisomer thereof.

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