A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/18 (2006.01) A61K 39/44 (2006.01) A61K 47/42 (2006.01) A61K 51/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2066031
Methods for reducing non-target retention of active moieties associated with immunoconjugates and their metabolites, and more specifically, for reducing renal retention of such active moieties, are disclosed. Methods of the present invention comprise administering an effective amount of a non-target reduction moiety, such as lysine, in addition to a therapeutically or diagnostically effective amount of an immunoconjugate. The non-target reduction moiety localizes in the kidneys and inhibits renal retention and reabsorption of active moieties associated with immunoconjugates and their metabolites.
L'invention concerne des procédés de réduction de la rétention non ciblée de fractions actives associées à des immunoconjugués et leurs métabolites, et plus spécifiquement, de réduction de la rétention rénale de telles fractions actives. Des procédés de la présente invention consistent à administrer une quantité efficace d'une fraction de réduction non ciblée, telle que la lysine, en plus d'une quantité thérapeutiquement ou diagnostiquement efficace d'un immunoconjugué. La fraction de réduction non ciblée se localise dans les reins et inhibe la rétention rénale et la réabsorption de fractions actives associées à des immunoconjugués et leurs métabolites.
Axworthy Don
Gray Mary A.
Wilkening David
Neorx Corporation
Smart & Biggar
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