Compositions and methods for the therapy and diagnosis of...

Details Compositions and methods for the therapy and diagnosis of... Compositions and methods for the therapy and diagnosis of...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 17/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2380873

Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

L'invention concerne des compositions et des techniques de thérapie et de diagnostic du cancer, tel que le cancer du poumon. Ces compositions peuvent renfermer au moins une protéine d'une tumeur pulmonaire, des parties immunogènes de celle-ci, ou des polynucléotides codant pour ces parties. Selon un autre mode de réalisation, une composition thérapeutique peut renfermer une cellule qui présente un antigène qui exprimant une protéine de tumeur pulmonaire, ou un lymphocyte T spécifique à des cellules exprimant cette protéine. On peut utiliser ces compositions, par exemple, pour prévenir et traiter des maladies telles que le cancer du poumon. L'invention concerne également des techniques diagnostiques basées sur la détection d'une protéine de tumeur pulmonaire, ou d'un ARNm codant pour cette protéine, dans un échantillon.

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