Polymer conjugates to therapeutic agents via an si-n and/or...

Details Polymer conjugates to therapeutic agents via an si-n and/or... Polymer conjugates to therapeutic agents via an si-n and/or...

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2615861

Therapeutic polymers are described, which contain at least one polymeric portion and at least one therapeutic agent. The therapeutic agent and the polymeric portion are covalently linked via one or more linkages which hydrolyze in an aqueous environment, for example, one or more linkages selected from an Si - N linkage, an Si - O linkage, and a combination of the same. Other aspects the invention are directed to methods of making the above therapeutic polymers.

La présente invention concerne des polymères thérapeutiques qui contiennent au moins une partie polymères et au moins un agent thérapeutique. L'agent thérapeutique et la partie polymère sont liés de manière covalente via une ou plusieurs liaisons qui hydrolysent dans un environnement aqueux, par exemple une ou plusieurs liaisons sélectionnées parmi une liaison Si - N, une liaison Si - O ou une combinaison de celles-ci. D'autres aspects de l'invention concernent les procédés de fabrication de ces polymères thérapeutiques.

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