Quinoline thiazolinones with cdk1 antiproliferative activity

Details Quinoline thiazolinones with cdk1 antiproliferative activity Quinoline thiazolinones with cdk1 antiproliferative activity

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2571732

The present invention provides new thiazolinone disubstituted quinoline derivatives, where the quinoline ring is disubstituted at the 3, 4 positions, of formula (I) which derivatives demonstrate CDK1 antiproliferative activity and are therefore useful as anti-cancer agents.

La présente invention concerne de nouveaux dérivés quinoline disubstitués thiazolinone dans lesquels le noya quinoline est disubstitué aux positions 3, 4 de la formule (I). Faisant preuve d'une activité antiproliférante anti-CDK1, ces dérivés conviennent particulièrement comme anticancéreux.

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