Sulfonamide derivatives as gamma secretase inhibitors

Details Sulfonamide derivatives as gamma secretase inhibitors Sulfonamide derivatives as gamma secretase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/4462 (2006.01) A61K 31/4468 (2006.01) A61K 31/453 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07D 207/14 (2006.01) C07D 211/56 (2006.01) C07D 211/58 (2006.01) C07D 211/62 (2006.01) C07D 211/96 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D

Patent

CA 2455861

Novel aryl and heteroaryl sulfonamides are disclosed. The sulfonamides, which are gamma secretase inhibitors, are represented by the formula: (I), wherein Ar1 and Ar2 independently represent aryl or heteroaryl and Y represents a bond or a (C(R3)2)1-3 group. Also disclosed is a method of inhibiting gamma secretase, and a method of treating Alzheimer s disease using the compounds of formula I.

La présente invention concerne de nouveaux sulfonamides aryles et hétéroaryles. Lesdits sulfonamides, qui sont des inhibiteurs de gamma-sécrétase, sont représentés par la formule: (I), où Ar?1¿et Ar?2¿ représentent indépendamment aryle et hétéroaryle et Y représente une liaison ou un groupe - (C(R?3¿)¿2?)¿1-3?. L'invention concerne également une méthode d'inhibition de la gamma-sécrétase et une méthode de traitement de la maladie d'Alzheimer à l'aide des composés de formule I.

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