Halogen compounds having thrombopoietin receptor agonism

Details Halogen compounds having thrombopoietin receptor agonism Halogen compounds having thrombopoietin receptor agonism

C - Chemistry, Metallurgy

07

D

C07D 277/46 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/429 (2006.01) A61K 31/4439 (2006.01) A61K 31/5377 (2006.01) A61P 7/02 (2006.01) A61P 7/04 (2006.01) A61P 43/00 (2006.01) C07D 277/60 (2006.01) C07D 277/84 (2006.01) C07D 417/14 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2435143

Compounds represented by the following general formula (III), prodrugs thereof, pharmaceutically acceptable salts thereof or solvates of the same which have a thrombopoietin agonism: (III) wherein R9 represents hydrogen, optionally substituted lower alkyl, etc.; R10, R11 and R12 independently represent each optionally substituted alkyl, halogeno, etc.; R14s independently represent each lower alkyl, halogeno, etc.; n is an integer of 0 to 2; and the ring A3 is a group represented by the following formula: (wherein R13 represents hydrogen or lower alkyl; and T represents oxygen or sulfur).

La présente invention concerne des composés représentés par la formule (III), des précurseurs de médicament, des sels et des solvates pharmaceutiquement acceptables de ces derniers qui ont un agonisme envers la thrombopoïétine. Dans la formule, R?9¿ représente hydrogène, alkyle inférieur éventuellement substitué ou similaires; R?10¿, R?11¿ et R?12¿ représentent chacun indépendamment alkyle substitué, halogéno ou similaires; les R?14¿ représentent chacun indépendamment alkyle inférieur, halogéno ou similaires; n est un entier tel que 0, 1 ou 2 et le cycle A?3¿ est un groupe représenté par la formule (II), dans laquelle R?13¿ représente hydrogène ou alkyle inférieur et T représente oxygène ou soufre. Formules (II) et (III)

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