Dsp-3 dual-specificity phosphatase

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/52 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2377670

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-3, and polypeptide variants thereof that stimulate dephosphorylation of DSP-3 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-3 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

La présente invention concerne des compositions et des procédés destinés au traitement de troubles associés aux prolifération, différentiation et durée de vie cellulaires. Elle concerne, en particulier, la phosphatase DSP-3 à spécificité double et des variants polypeptides de cette phosphatase qui stimulent une déphosphorylation de substrats à DSP-3. Les polypeptides peuvent être utilisés, par exemple, dans l'identification d'anticorps et d'autres agents qui inhibent l'activité DSP-3. Ces polypeptides et agents peuvent être utilisés afin de moduler les prolifération, différentiation et durée de vie cellulaires.

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