A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/5685 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2605796
The present invention relates to pharmaceutical compositions and methods of treatment comprising administering to a patient in need thereof a combination of a 2-(-)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8- tetrahydronaphthalene-2-ol or a pharmaceutically acceptable salt or prodrug thereof and an aromatase inhibitor. Particularly, the present invention relates to pharmaceutical compositions and methods of treatment comprising administering to a patient in need thereof (-)-cis-6-phenyl-5-[4-(2-pyrrolidin- 1-yl-ethoxy)-phenyl]-5,6,7,8- tetrahydronaphthalene-2-ol or a pharmaceutically acceptable salt or prodrug and an aromatase inhibitor selected from aminoglutethimide; formestane; atamestane; anastrazole; fadrozole; finrozole; letrozole; vorozole; 4-[N-(4-bromobenzyl)-N-(4-cyanophenyl)amino]-4H-1,2,4- triazole or exemestane, or a pharmaceutically acceptable salt thereof.
L'invention concerne des compositions pharmaceutiques et des méthodes de traitement consistant à administrer à un patient nécessitant un tel traitement une combinaison d'un 2-(-)-cis-6-phényl-5-[4-(2-pyrrolidin-1 -yl-éthoxy)-phényl]-5,6,7,8-tétrahydronaphtalène-2-ol ou d'un sel ou d'un promédicament pharmaceutiquement acceptables de ce celui-ci, et d'un inhibiteur de l'aromatase. L'invention concerne en particulier des compositions pharmaceutiques et des méthodes de traitement consistant à administrer à un patient nécessitant un tel traitement, du (-)-cis-6-phényl-5-[4-(2-pyrrolidin-1-yl-éthoxy)-phényl]-5,6,7,8- tétrahydronaphtalène-2-ol ou un sel ou un promédicament pharmaceutiquement acceptables de celui-ci, et un inhibiteur de l'aromatase sélectionné parmi aminoglutéthimide; forméstane; ataméstane; anastrazole; fadrozole; finrozole; létrozole; vorozole; 4-[N-(4-bromobenzyl)-N-(4-cyanophényl)amino]-4H-1,2,4-triazole ou exémestane, ou un sel pharmaceutiquement acceptable de ceux-ci.
Curto Madelyn
Lee Andrew George
Sisson Melanie
Thompson David Duane
Pfizer Products Inc.
Smart & Biggar
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