C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 9/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2401741
The invention provides for an isolated nucleic acid encoding Mda-5 (melanoma differentiation associated gene-5) and an isolated Mda-5 polypeptide. The invention further provides a vector comprising the nucleic acid encoding Mda- 5, as well as a host cell comprising the vector. The invention provides an antibody which specifically binds to an Mda-5 polypeptide. The invention further provides a method for determining whether a compound is an inducer of Mda-5 gene expression and assays to determine whether a compound modifies the enzymatic activity of the Mda-5 polypeptide.
L'invention concerne un acide nucléique isolé codant pour Mda-5 (gène-5 associé à la différentiation des mélanomes), et un polypeptide Mda-5 isolé. L'invention concerne également un vecteur comprenant l'acide nucléique codant pour Mda-5, ainsi qu'une cellule hôte comprenant ledit vecteur. L'invention concerne, en outre, un anticorps se liant de manière spécifique à un polypeptide Mda-5. L'invention concerne enfin une méthode permettant de déterminer si un composé est un inducteur d'expression du gène Mda-5, ainsi que des dosages permettant de déterminer si un composé modifie l'activité enzymatique du polypeptide Mda-5.
Fisher Paul B.
Gopalkrishnan Rahul V.
Kang Dong-Chul
Osler Hoskin & Harcourt Llp
The Trustees Of Columbia University In The City Of New York
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