Sulfonyloxazolamines as therapeutic active compounds

Details Sulfonyloxazolamines as therapeutic active compounds Sulfonyloxazolamines as therapeutic active compounds

C - Chemistry, Metallurgy

07

D

C07D 263/48 (2006.01) A61K 31/42 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2356134

The present invention relates to sulphonyloxazolamines of general formula (I), wherein R1, R2 represent independently from each other H, A, -(CH2)n-Ar or alkenyl with 2-6 C atoms, R1 and R2 together also represent a mononuclear saturated heterocycle with 1-2 N, O and/or S atoms, Z is H, A, CF3, NO2, Hal, OH, OA, NH2, NHA or NA2, A represents alkyl with 1-6 C atoms, Ar is Z- monosubstituted or Z-disubstituted phenyl, Hal is F, Cl, Br or I, n is 1 or 2 or the physiologically acceptable salts or solvates thereof. Said sulphonyloxazolamines are used as therapeutic active ingredients. The invention also relates to the use of sulphonyloxazolamines as therapeutic active ingredients and/or to the production of pharmaceutical preparations to combat diseases of the central nervous system. The invention further relates to a pharmaceutical preparation and the production thereof.

Sulfonyloxazolamines de formule générale (I) dans laquelle R?1¿ et R?2¿ représentent, indépendamment l'un de l'autre, H, A, -(CH¿2?)¿n?-Ar ou alcényle ayant 2 à 6 atomes de C, R?1¿ et R?2¿ représentent ensemble également un hétérocycle saturé à un seul noyau ayant 1 à 2 atomes de N, O et/ou S, Z représente H, A, CF¿3?, NO¿2?, Hal, OH, OA, NH¿2?, NHA ou NA¿2?, A représente alkyle ayant 1 à 6 atomes de C, Ar représente phényle monosubstitué ou disubstitué par Z, Hal représente F, Cl, Br ou I, n représente 1 ou 2, ou leurs sels ou solvats acceptables sur le plan physiologique, en tant que principes actifs thérapeutiques. La présente invention concerne également l'utilisation desdites sulfonyloxazolamines en tant que principes actifs thérapeutiques et/ou pour la fabrication de préparations thérapeutiques destinées à lutter contre des maladies du système nerveux central, une préparation thérapeutique et la fabrication de ladite préparation.

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