A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2483552
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
L'invention concerne des procédés relatifs à l'élaboration de conjugués de type médicament cytotoxique monomère/vecteur, offrant une charge en médicament largement supérieure à celle qui correspond à l'état antérieur de la technique, ainsi qu'une agrégation réduite et une faible fraction de conjugué. L'invention concerne également des conjugués de type dérivé de médicament cytotoxique/anticorps, des compositions renfermant les conjugués, et des utilisations relatives aux conjugués. L'invention concerne par ailleurs des conjugués de type dérivé de calichéamicine monomère/anticorps anti-CD22, des compositions renfermant les conjugués, et des utilisations relatives aux conjugués.
Damle Nitin Krishnaji
Dijoseph John Francis
Jain Neera
Kunz Arthur
Merchant Nishith
Torys Llp
Wyeth Holdings Corporation
LandOfFree
Calicheamicin derivative-carrier conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Calicheamicin derivative-carrier conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Calicheamicin derivative-carrier conjugates will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1367772