Methylation markers for prognosis and treatment of cancers

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/04 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2616601

Genes for thirteen DNA damage repair or DNA damage response enzymes can be epigenetically silenced in cancers. The silencing of nucleic acids encoding a DNA repair or DNA damage response enzyme can be used prognostically and for selecting treatments that are well tailored for an individual patient. Combinations of these markers can also be used to provide prognostic information. Kits for testing epigenetic silencing can be used to determine a prognosis or a therapeutic regimen.

Selon l'invention, des gènes pour treize enzymes de réparation de dommages à l'ADN ou de réponse aux dommages à l'ADN peuvent être soumis à un silençage épigénétique dans les cancers. Le silençage d'acides nucléiques codant pour une enzyme de réparation d'ADN ou de réponse aux dommages à l'ADN peut être utilisé en vue d'un pronostic et pour sélectionner des traitements adaptés à un patient individuel. Des combinaisons de ces marqueurs peuvent également être utilisées pour obtenir des informations de pronostic. Des trousses destinées à tester le silençage épigénétique peuvent être utilisées pour déterminer un pronostic ou un régime thérapeutique.

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