C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2389333
The present invention relates to a stable crystalline form of N-(3- ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quina- zolinamine hydrochloride designated the B polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph B form of N- (3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4- quinazolinamine as hydrochloride, as well as other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
La présente invention concerne une forme cristalline stable de chlorhydrate de N-(3-éthynylphényl)-6,7-bis(2-méthoxyéthoxy)-4-quinazolinamine appelée polymorphe B, ainsi que sa production sous une forme sensiblement pure et son utilisation. L'invention concerne également des compositions pharmaceutiques contenant ladite forme polymorphique stable B de N-(3-éthynylphényl)-6,7-bis(2-méthoxyéthoxy)-4-quinazolinamine comme chlorhydrate et d'autres formes du composé, ainsi que des méthodes de traitement de maladies hyperprolifératives, notamment le cancer, basées sur l'administration dudit composé.
Connell Richard D.
Ferrante Karen J.
Foster Barbara A.
Kajiji Shama M.
Morin Michael J.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Osi Pharmaceuticals Inc.
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