Difluoroglutamic acid conjugates with folates and...

C - Chemistry – Metallurgy – 07 – C

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C07C 229/24 (2006.01) A61K 31/19 (2006.01) A61K 31/225 (2006.01) C07C 233/81 (2006.01) C07C 237/36 (2006.01) C07D 475/08 (2006.01)

Patent

CA 2040059

ABSTRACT This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias. MO1468

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