Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4188 (2006.01) A61K 31/424 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2527533

The present invention relates to bicyclic dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

L'invention concerne des composés bicycliques dihydropyrrole utiles pour traiter des maladies de prolifération cellulaire, des maladies associées à l'activité kinésine KSP et pour inhiber la kinésine KSP. La présente invention porte également sur des compositions contenant ces composés et sur des procédés d'utilisation pour traiter le cancer chez les mammifères.

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