Liquid formulation of fsh

Details Liquid formulation of fsh Liquid formulation of fsh

A - Human Necessities

61

K

A61K 47/10 (2006.01) A61K 9/00 (2006.01) A61K 38/24 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2713386

The present invention relates to a liquid pharmaceutical composition comprising a follicle stimulating hormone polypeptide and benzalkonium chloride and benzyl alcohol as preservatives. The composition further comprises optionally one or more other pharmaceutically acceptable excipients. In one embodiment, the composition contains methionine as an antioxidant. The composition shows a good storage stability and is especially useful for the prophylaxis and treatment of disorders and medical indications where follicle stimulating hormone preparations are considered as useful remedies.

La présente invention concerne une composition pharmaceutique liquide qui comprend un polypeptide de l'hormone de stimulation folliculaire ainsi que du chlorure de benzalkonium et de l'alcool benzylique en tant que conservateurs. La composition comprend en outre éventuellement un ou plusieurs autres excipients pharmaceutiquement acceptables. Dans un mode de réalisation, la composition contient de la méthionine en tant qu'antioxydant. La composition présente une bonne stabilité au stockage et est notamment utile pour la prophylaxie et le traitement de troubles et d'indications médicales pour lesquels des préparations d'hormone de stimulation folliculaire sont considérées comme des traitements utiles.

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