C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/734 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/235 (2006.01) A61K 31/255 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/421 (2006.01) A61K 31/428 (2006.01) A61K 31/4353 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/47 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07C 59/62 (2006.01) C07C 59/68 (2006.01) C07C 59/72 (2006.01) C07C 205/56 (
Patent
CA 2477208
A compound represented by the formula (I) or a salt thereof: (see formula I) wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R1(CH2)k- (wherein k represents 0 or an integer of 1 to 3; R1 represents a saturated cyclic alkyl group having 3 to 7 carbon atoms or a saturated condensed cyclic alkyl group having 6 to 8 carbon atoms, and the group R1 may be substituted with a lower alkyl group having 1 to 4 carbon atoms) and the like, and Ar represents a condensed bicyclic group such as naphthalen-1-yl group, which has suppressing action on prostaglandin and leukotriene production and is useful for prophylactic and/or therapeutic treatment of various inflammatory diseases and the like caused by these lipid mediators.
L'invention porte sur un composé représenté par la formule générale (I) [dans laquelle n est un nombre entier compris entre 1 et 3 ; R représente alkyle C3-8, un groupe représenté par R1(CH2)k- (k est un nombre entier compris entre 0 et 3 ; et R1 représente cycloalkyle C3-7 saturé ou alkyle saturé à noyau condensé C6-8, à condition que R1 puisse être substitué par alkyle C1-4), etc. ; et Ar représente un groupe bicyclique à noyau condensé tel que naphatalène-1-yl], ou sur un sel de ce composé. Le composé ou son sel a une activité inhibitrice de la production de prostaglandines et de leucotriènes. Il est notamment utile dans la prévention et les traitements de diverses maladies inflammatoires imputables au médiateur lipidique.
Kuriyama Hiroshi
Shoda Motoshi
Asahi Kasei Pharma Corporation
Goudreau Gage Dubuc
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