Method for detecting free igfbp-1

Details Method for detecting free igfbp-1 Method for detecting free igfbp-1

G - Physics

01

N

G01N 33/543 (2006.01) G01N 33/558 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2189050

A method and device is described for detecting fetal membrane rupture by detecting only that insulin-like growth factor-binding protein 1 (IGFBP-1) which is free of insulin- like growth factors 1 and 2 (IGF-1 and IGF-2). The method is based on the fact that the concentration of free IGFBP-1 in the blood serum is about ten times lower than that of the IGFBP-1 bound to IGF-1 and IGF-2, while the amniotic liquid which is contained in the amnion has more than 1000 times the concentration of free IGFBP-1 than the blood serum. The device comprises a one pad (22) and two strips (24, 26) test kit which may be used to detect free IGFBP-1 in a range of concentrations from 5 ng/ml to 250 µg/ml.

L'invention se rapporte à un procédé et à un dispositif de détection de la rupture de la membrane foetale par détection, uniquement, de la protéine de liaison 1 du facteur de croissance insulinoïde (IGFBP-1) qui n'est pas fixée aux facteurs de croissance insulinoïdes 1 et 2 (IGF-1 et IGF-2). Le procédé est basé sur le fait que la concentration d'IGFBP-1 libre dans le sérum sanguin est environ dix fois inférieure à celle d'IGFBP-1 fixée à IGF-1 et IGF-2, alors que le liquide amniotique contenu dans l'amnios a une concentration en IGFBP-1 libre 1000 fois supérieure à celle du sérum sanguin. Le dispositif comprend un kit de test - un tampon (22) et deux bandelettes (24, 26) - qui peut être utilisé pour détecter l'IGFBP-1 libre dans une plage de concentrations comprises entre 5 ng/ml et 250 µg/ml.

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