C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2586106
The invention relates to novel sulfamic acid amides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists. General Formula (I) wherein R1 represents -CH(OH)-CH3, -CH2-CH2OH, -CH2COOH, -CH2-CH2-CH2OH, -CH2-CH2-COOH, R2 represents 4-bromophenyl, 4-chlorophenyl, 4-methylphenyl, 2-methoxyphenoxy, 3-methoxyphenoxy, 2-chloro-5-methoxy-phenoxy, R3 represents bromine or chlorine, and optically pure enantiomers, mixtures of enantiomers such as racemates, and pharmaceutically acceptable salts thereof.
L'invention concerne de nouveaux amides d'acide sulfamique et leur utilisation comme ingrédients actifs dans la préparation de compositions pharmaceutiques. L'invention concerne également des aspects associés, y compris des compositions pharmaceutiques contenant un ou plusieurs de ces composés et, en particulier, leur utilisation comme antagonistes du récepteur de l'endothéline.
Bolli Martin
Boss Christoph
Clozel Martine
Fischli Walter
Weller Thomas
Actelion Pharmaceuticals Ltd
Gowling Lafleur Henderson Llp
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