Attenuated mutants of salmonella which constitutively...

Details Attenuated mutants of salmonella which constitutively... Attenuated mutants of salmonella which constitutively...

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) A61K 39/00 (2006.01) A61K 39/112 (2006.01) A61P 31/04 (2006.01) C12N 1/20 (2006.01) C12N 1/36 (2006.01) C12N 15/74 (2006.01) C07K 14/255 (2006.01)

Patent

CA 2328056

Attenuated Salmonella mutants which constitutively express the Vi antigen are disclosed, as well as vaccines against typhoid fever containing the same, live vector vaccines containing the same, and DNA-mediated vaccines containing the same.

Cette invention, qui a trait à des mutants atténués de Salmonella exprimant de manière constitutive l'antigène Vi, porte également sur des vaccins contre la fièvre typhoïde, des vaccins à vecteur vivant ainsi que sur des vaccins dont le médiateur est de l'ADN, lesquels vaccins renferment ces mutants.

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