Novel pyrazole derivatives, method of preparing them and...

Details Novel pyrazole derivatives, method of preparing them and... Novel pyrazole derivatives, method of preparing them and...

C - Chemistry, Metallurgy

07

D

C07D 231/14 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 231/12 (2006.01) C07D 231/40 (2006.01) C07D 401/02 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07D 453/02 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2098944

The invention relates to compounds of formula: (see fig. I) in which - g2, g3, g4, g5 and g6 and w2, w3, w4, w5 and w6 are identical or different and are independently hydrogen, a chlorine or bromine atom, a (C1-C3)alkyl, a (C1-C3)-alkoxy, a trifluoromethyl or a nitro group and g4 is optionally a phenyl group; - R4 is hydrogen or a (C1-C3)-alkyl; - X is either a direct bond or a group -(CH2)x-N(R3)-, in which R3 is hydrogen or a (C1-C3)-alkyl and x is zero or one; and - R is - a group -NR1R2 in which R1 and R2 are independently a (C1-C6)-alkyl; an optionally-substituted non- aromatic (C3-C15) carbocyclic radical ; an amino (C1-C4) alkyl group in which the amino is optionally disubstituted by a (C1-C3)-alkyl; a cycloalkyl-(C1-C3) alkyl in which the cycloalkyl is C3-C12; a phenyl which is unsubstituted or monosubstituted or polysubstituted by a halogen, by a (C1-C5)-alkyl or by a (C1-C5)-alkoxy; a phenyl (C1-C3)-alkyl; a diphenyl-(C1-C3)- alkyl; a naphthyl; an anthracenyl; a saturated 5- to 8-membered heterocyclic radical which is unsubstituted or substituted by a (C1-C3)- alkyl, by a hydroxyl or by a benzyl group ; a 1-adamantylmethyl an aromatic heterocycle unsubstituted , mono or-polysubstituted by a halogen, a (C1-C5)alkyl, a (C1-C5)-alkoxy or a (C1-C3)-alkyl substituted by an aromatic heterocycle unsubstituted or mono- or - polysubstituted by a halogen, a (C1-C5) alkyl, a (C1-C5)-alkoxy,or else R1 is hydrogen and R2 is as defined above, or else R1 and R2, together with the nitrogen atom to which they are bonded, form a saturated 5- to 8-membered heterocyclic radical, said heterocyclic radical being other than morpholine when w2, w3, w4, w5 and w6 and g2, g3, g4, g5 and g6 are all hydrogen; - a group R2 as defined above when X is -(CH2)x N(R3)-; or - a group R5 when X is a direct bond, R5 being a (C1-C3)-alkyl; a (C3-C12)-cycloalkyl which is unsubstituted or substituted by a (C1-C5)-alkyl; a phenyl-(C1-C3)-alkyl which is unsubstituted or substituted by a halogen or by a (C1-C5)-alkyl; a cycloalkyl-(C1-C3)-alkyl in which the cycloalkyl is C3-C12 and is unsubstituted or substituted by a (C1-C5)-alkyl; or a 2-norbornylmethyl; or one of their salts, where appropriate. These compounds are useful as pharmaceuticals in the therapeutic areas in which cannabis is known to be involved.

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