Methods for treating fibrotic conditions

Details Methods for treating fibrotic conditions Methods for treating fibrotic conditions

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 39/00 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2609190

The present invention is directed to methods for treating fibrosis conditions, such as liver, kidney and lung fibrosis, as well as fibrosis conditions of other tissues of the body. The methods of the invention comprise administering to a patient in need of such treatment a therapeutically effective amount of a B-cell antagonist. Exemplary B-cell antagonists that can be used in the practice of the methods of the invention include antibodies against B-cell surface antigens (e.g., antibodies against CD20), and BAFF antagonists.

L'invention concerne des méthodes pour traiter des troubles fibrotiques, notamment une fibrose du foie, du rein et du poumon, ainsi que des troubles fibrotiques d'autres tissus du corps. Ces méthodes consistent à administrer à un patient nécessitant un tel traitement, une quantité thérapeutiquement efficace d'un antagoniste de cellule B. Des antagonistes de cellules B d'exemple pouvant être utilisés pour pratiquer les méthodes de l'invention comprennent des anticorps dirigés contre les antigènes de surface des cellules B (par exemple, des anticorps dirigés contre CD20) et des antagonistes de BAFF.

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