C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/17 (2006.01) C07K 5/11 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2416260
The present invention provides substantially purified peptide portions of a promyostatin polypeptide. For example, the invention provides proteolytic fragments of a promyostatin polypeptide such as a myostatin prodomain or a mature myostatin peptide, as well as functional peptide portions a moystatin prodomain a myostatin. Also provided is a mutant promyostatin polypeptide, which is resistant to proteolytic cleavage, for example, cleavage into a myostatin prodomain and a mature myostatin peptide. The present invention also provides a polynucleotide encoding a peptide portion of a promyostatin polypeptide. In addition, antibodies that specifically bind a peptide portion of a promyostatin polypeptide are provided. The invention further provides methods of identifying a functional peptide portion of a promyostatin polypeptide.
La présente invention concerne des parties peptidiques sensiblement purifiées d'un polypeptide de la promyostatine. L'invention concerne, par exemple, des fragments protéolytiques d'un polypeptide de la promyostatine tels qu'un prodomaine de la myostatine ou un peptide mûr de la myostatine, ainsi que des parties peptidiques fonctionnelles d'un prodomaine de myostatine d'une myostatine. L'invention concerne également un polypeptide mutant de la myostatine qui est résistant au clivage protéolytique, par exemple au clivage en un prodomaine de myostatine et un peptide mûr de la myostatine. L'invention concerne également un polynucléotide codant une partie peptidique d'un polypeptide de la promyostatine. L'invention concerne en outre des anticorps qui se lient spécifiquement à une partie peptidique d'un polypeptide de la promyostatine. L'invention concerne enfin des procédés qui permettent d'identifier une partie peptidique fonctionnelle d'un polypeptide de la promyostatine.
Lee Se-Jin
Mcpherron Alexandra C.
Mbm Intellectual Property Law Llp
The Johns Hopkins University School Of Medicine
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