Use of pdt to inhibit intimal hyperplasia

Details Use of pdt to inhibit intimal hyperplasia Use of pdt to inhibit intimal hyperplasia

A - Human Necessities

61

K

A61K 41/00 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2391389

Long-term dialysis requires provision of safe and reliable vascular access, often in the form of an arteriovenous (AV) fistula. The primary cause of AV fistula loss or failure is stenosis caused by intimal hyperplasia (IH) in the graft at the venous anastomosis or the distal vein. Disclosed are methods of using photodynamic therapy (PDT) to inhibit IH in blood vessels which may also be used to inhibit IH and SMC growth at the anastomosis of an AV fistula in vivo.

La dialyse sur une longue période nécessite un accès vasculaire sûr et fiable, souvent sous la forme d'une fistule artério-veineuse. La première cause de perte ou de défaillance de cette fistule est la sténose provoquée par l'hyperplasie de l'intima dans la greffe au niveau de l'anastomose veineuse ou de la veine distale. L'invention concerne des procédés d'utilisation d'une thérapie photodynamique destinée à empêcher cette hyperplasie dans des vaisseaux sanguins, thérapie que l'on peut également utiliser pour inhiber l'hyperplasie de l'intima et la croissance des cellules musculaires lisses, au niveau de l'anastomose d'une fistule artério-veineuse in vivo.

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