Methods for producing protein c

Details Methods for producing protein c Methods for producing protein c

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C12N 5/02 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2138101

The present invention relates to a method for producing high levels of functional recombinant proteins in adenovirus-transformed mammalian cells by incubating cells capable of producing recombinant proteins at a temperature range between about 38 degrees centigrade and about 39 degrees centigrade. The method allows for higher levels of expression of total protein in some cell lines and higher levels of functional protein in other cell lines.

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