C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/062 (2006.01) A61K 31/198 (2006.01) A61K 38/05 (2006.01) A61P 25/28 (2006.01) C07C 237/06 (2006.01) C07K 5/06 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2472617
The present invention relates to compounds of formula (I) useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharamaceutical compositions and methods of treatment to reduce A beta peptide formation.
L'invention concerne des composés de formule (I) qui sont utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies similaires. Ces composés comprennent des inhibiteurs de l'enzyme bétasécrétase qui sont utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par un dépôt de peptide béta-amyloïde (A-béta peptide) chez un mammifère. Les composés selon l'invention sont utiles dans des compositions pharmaceutiques et des méthodes de traitement permettant de réduire la formation de A-béta peptide.
Jagodzinska Barbara
Warpehoski Martha A.
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company
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