Fused ring heteroaryl and heterocyclic compounds which...

Details Fused ring heteroaryl and heterocyclic compounds which... Fused ring heteroaryl and heterocyclic compounds which...

C - Chemistry, Metallurgy

07

D

C07D 235/30 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/517 (2006.01) A61P 3/00 (2006.01) A61P 7/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) C07D 239/94 (2006.01) C07D 239/95 (2006.01) C07D 263/58 (2006.01) C07D 277/82 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2359112

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

L'invention concerne des composés se fixant à VLA-4. Certains de ces composés inhibent également l'adhésion des leucocytes et, en particulier, l'adhésion des leucocytes provoquée par VLA-4. Ces composés sont utiles pour le traitement de maladies inflammatoires chez un mammifère, par exemple l'homme, telles que l'asthme, la maladie d'Alzheimer, l'athérosclérose, la démence du SIDA, le diabète, la maladie inflammatoire intestinale, la polyarthrite rhumatoïde, la transplantation de tissus, la métastase tumorale et l'ischémie myocardique. On peut également administrer ces composés pour le traitement de maladies cérébrales inflammatoires, telles que la sclérose multiple.

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