Process for the production of alpha-6-deoxytetracyclines

Details Process for the production of alpha-6-deoxytetracyclines Process for the production of alpha-6-deoxytetracyclines

C - Chemistry, Metallurgy

07

C

C07C 237/26 (2006.01) C07C 231/12 (2006.01)

Patent

CA 2044612

2044612 9007492 PCTABS00001 A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylene tetracyclines is described using a silica-supported heterogeneous rhodium catalyst of general formula (I), wherein R and R' are each selected from hydrogen and C1-C4 alkyl; x is an integer from 1 to 6; Ph is phenyl; y is an integer from 1 to 3; and L is a ligand selected from alkoxysilyl-substituted alkyldiphenyl phosphines. The process stereospecifically produces the alpha epimers at higher yields while using lower rhodium metal levels than prior methods.

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