C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/16 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2275477
The present invention generally relates to protein binding fragments of gravin and polynucleotides encoding these fragments. The protein binding fragments include fragments which bind to the Type II regulatory subunit of cAMP- dependent protein kinase or protein kinase C. This invention further provides antibodies to the protein binding fragments and assays for identifying compounds which modulate the binding of gravin to the binding protein.
L'invention concerne, de façon générale, des fragments de gravine de liaison aux protéines et des polynucléotides codant ces fragments. Les fragments de liaison aux protéines comprennent les fragments qui se lient à la sous-unité régulatrice de type II de protéine-kinase AMPc-dépendante ou de protéine-kinase C. L'invention concerne en outre des anticorps dirigés contre les fragments de liaison aux protéines et les tests d'identification de composés modulant la liaison de la gravine à la protéine liante.
Klauck Theresa M.
Nauert J. Brian
Scott John D.
Oregon Health Sciences University
Smart & Biggar
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