A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C12Q 1/02 (2006.01) C12Q 1/44 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2242866
A general feature of the present invention is the induction of the death of stimulated cells by a Ca2+ influx blocker. The invention, in its various aspects, includes administration of compositions that induce cell death including administration of a composition to a mammal, e.g., a human for therapeutic purposes; compositions, e.g., a composition having a Ca2+ influx blocker and an agent which normally stimulates cells in which cell death is to be induced; kits of compositions, e.g., a kit having a Ca2+ influx blocker and an agent which normally stimulates cells in which cell death is to be induced; use of such compositions or kits of compositions as anti-inflammatory agents and/or anti-proliferative agents; and use of a Ca2+ influx blocker or use of Ca2+ influx blocker and agent in the preparation of a medicament for use in inducing cell death. The invention includes a method for diagnosing the susceptibility of diseased animals to treatment with a Ca2+ influx blocker or the combination of a Ca2+ influx blocker and agent which normally stimulates cells in order that the treatment can induce cell death. The invention includes a method for screening potential compounds as Ca2+ influx blockers.
La caractéristique générale de l'invention est l'induction de la mort de cellules stimulées par un antagoniste du Ca?2+¿. L'invention, dans ses divers aspects, comprend l'administration de compositions qui induisent la mort cellulaire, entre autres l'administration d'une composition à un mammifère, humain par exemple, à des fins thérapeutiques; elle concerne également des compositions, par exemple une composition contenant un antagoniste du Ca?2+¿ et un agent stimulant normalement les cellules dont on cherche à provoquer la mort, des trousses contenant ces compositions, par exemple une trousse comportant un antagoniste du Ca?2+¿ et un agent stimulant normalement les cellules dont on cherche à provoquer la mort, l'utilisation de ces compositions ou de ces trousses comme agents anti-inflammatoires et/ou anti-prolifératifs, et l'utilisation d'un antagoniste du Ca?2+¿, ou bien d'un antagoniste du Ca?2+¿ et d'un agent, pour la préparation d'un médicament destiné à provoquer la mort cellulaire. L'invention comprend une méthode permettant de diagnostiquer la susceptibilité d'animaux malades au traitement au moyen d'un antagoniste du Ca?2+¿, ou de la combinaison de celui-ci avec un agent stimulant normalement les cellules, ledit traitement étant susceptible de provoquer leur mort. L'invention comprend une méthode permettant de cribler des composés potentiels pouvant faire office d'antagonistes du Ca?2+¿.
Berger Stuart Alan
Gommerman Jennifer Lynn
Blake Cassels & Graydon Llp
The Wellesley Hospital Foundation
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