Fgf variants and methods for use thereof

Details Fgf variants and methods for use thereof Fgf variants and methods for use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01)

Patent

CA 2483602

The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced activity that act as improved agonists and variants having reduced activity that act as antagonists. Methods of utilizing preferred FGF variants in preparation of medicaments for the treatment of skeletal disorders including skeletal dysplasia, osteoporosis and enhancing bone fracture healing and cartilage healing processes are provided.

L'invention concerne des variantes du facteur de croissance des fibroblastes, possédant la spécificité de sous-type de récepteur amélioré et/ou une affinité vis-à-vis de celui-ci. Dans les modes de réalisation préférés, l'invention concerne deux variantes possédant une activité accrue agissant comme des d'antagonistes. Sont également décrites, des méthodes d'utilisation des variantes de FGF préférées dans la préparation de médicaments pour le traitement de troubles du squelette, dont la dysplasie du squelette et l'ostéoporose, et pour l'amélioration de la réparation de fractures osseuses et dans des processus de réparation du cartilage.

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